Hydrochloric Acid

Hydrochloric Acid

SCHEMBL920895

Cc1ccc(S(=O)(=O)NC(CCCCN)C(=O)CCl)cc1.Cl

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ITGB3 known ✓ P05106 1/20 0.45
ITGA2B known ✓ P08514 1/20 0.45
CA2 known ✓ P00918 4/20 0.43
MMP13 known ✓ P45452 2/20 0.41
MMP1 known ✓ P03956 1/20 0.41
MMP8 known ✓ P22894 1/20 0.41
MMP2 P08253 4/20 0.56
MMP9 P14780 2/20 0.56
PLAU P00749 4/20 0.47
HPN P05981 4/20 0.47
TDP1 Q9NUW8 1/20 0.44
SLC1A3 P43003 1/20 0.43
SLC1A2 P43004 1/20 0.43
SLC1A1 P43005 1/20 0.43
CA12 O43570 2/20 0.43
CA9 Q16790 2/20 0.43
CA1 P00915 3/20 0.43
CA14 Q9ULX7 1/20 0.41
MMP3 P08254 1/20 0.41
KDM4E B2RXH2 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11406948 1.00 MMP2 (0.56) MMP2MMP9PLAUHPNITGB3
SCHEMBL200247 0.99 MMP2 (0.57) MMP2MMP9PLAUHPNITGB3
SCHEMBL200245 0.99 MMP2 (0.57) MMP2MMP9PLAUHPNITGB3
Hydrochloric Acid SCHEMBL15537019 0.96 MMP2 (0.55) MMP2MMP9PLAUHPNITGB3
SCHEMBL1305743 0.88 MMP2 (0.56) MMP2MMP9PLAUHPNITGB3
SCHEMBL1305745 0.88 MMP2 (0.56) MMP2MMP9PLAUHPNITGB3
Hydrochloric Acid SCHEMBL1499337 0.87 MMP9 (0.65) MMP2MMP9PLAUHPNITGB3
Hydrochloric Acid SCHEMBL14059214 0.87 MMP9 (0.65) MMP2MMP9PLAUHPNITGB3
SCHEMBL5490595 0.86 PLAU (0.45) MMP2MMP9PLAUHPNITGB3
Hydrochloric Acid SCHEMBL9087107 0.86 MMP9 (0.74) MMP2MMP9PLAUHPNITGB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2722054-B1 Methods and compositions for oral administration of proteins ORAMED PHARMACEUTICALS INC (IL) 2018-03-21 EP claimed
EP-2722054-A1 Methods and compositions for oral administration of proteins Oramed Pharmaceuticals Inc. (IL) 2014-04-23 EP claimed
EP-1933862-A2 METHODS AND COMPOSITIONS FOR ORAL ADMINISTRATION OF PROTEINS Oramed Pharmaceuticals Inc. (IL) 2008-06-25 EP claimed
US-20070087957-A1 Methods and compositions for oral administration of proteins ORAMED PHARMACEUTICALS INC. (IL) 2007-04-19 US claimed
WO-2007029238-A2 METHODS AND COMPOSITIONS FOR ORAL ADMINISTRATION OF PROTEINS ORAMED PHARMACEUTICALS, INC. (IL) 2007-03-15 WO claimed
US-20060182722-A1 Methods and materials for isolating isogenic islet cells REGENTS OF THE UNIVERSITY OF MINNESOTA 2006-08-17 US claimed
EP-3873495-B1 METHODS AND COMPOSITIONS FOR TREATMENT OF TYPE 1 DIABETES USING FIBROBLASTS AS FACILITATORS OF ISLET ENGRAFTMENT FIGENE LLC (US) 2024-06-26 EP disclosed
CN-118019522-A Pharmaceutical composition comprising a large physiologically active substance and an excipient D&D制药技术股份有限公司 2024-05-10 CN disclosed
US-20240115619-A1 TREATMENT OF DIABETES BY ENHANCEMENT OF PANCREATIC ISLET ENGRAFTMENT THROUGH REGENERATIVE IMMUNE MODULATION CREATIVE MEDICAL TECHNOLOGIES, INC. (US) 2024-04-11 US disclosed
EP-4257143-A2 METHODS AND COMPOSITIONS FOR TREATMENT OF TYPE 1 DIABETES USING FIBROBLASTS AS FACILITATORS OF ISLET ENGRAFTMENT Figene, LLC (US) 2023-10-11 EP disclosed
US-20230240997-A1 METHOD OF TREATING CANCER THERASYN SENSORS INC (US) 2023-08-03 US disclosed
US-11660327-B2 Methods and compositions for oral administration of proteins ORAMED LTD. (IL) 2023-05-30 US disclosed
US-20220160839-A1 METHODS AND COMPOSITIONS FOR ORAL ADMINISTRATION OF PROTEINS ORAMED PHARMACEUTICALS, INC. (IL) 2022-05-26 US disclosed
WO-2007029238-A2 METHODS AND COMPOSITIONS FOR ORAL ADMINISTRATION OF PROTEINS ORAMED PHARMACEUTICALS, INC. (IL) 2007-03-15 WO disclosed
US-7150988-B2 Controlling proteolytic action in natural rubber latex ROCHE DIAGNOSTICS OPERATIONS, INC. (US) 2006-12-19 US disclosed
US-20060182722-A1 Methods and materials for isolating isogenic islet cells REGENTS OF THE UNIVERSITY OF MINNESOTA 2006-08-17 US disclosed
WO-2006063810-A1 CONTROLLING PROTEOLYTIC ACTION NATURAL RUBBER LATEX ROCHE DIAGNOSTICS GMBH (DE) 2006-06-22 WO disclosed
US-20060127970-A1 Controlling proteolytic action in natural rubber latex ALLERGEN REDUCTION, INC. 2006-06-15 US disclosed
EP-0624641-B1 Thermostable nucleic acid polymerase HOFFMANN LA ROCHE (CH) 2000-12-13 EP disclosed
EP-0624641-A2 Thermostable nucleic acid polymerase F. HOFFMANN-LA ROCHE AG (CH) 1994-11-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060182722-A1 Methods and materials for isolating isogenic islet cells IAPP, RNASE1, PNLIP ITGB3 238/4885ITGA2B 566/4885CA2 3758/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.