Mimbane

Mimbane

SCHEMBL123033

Cl.Cn1c2c(c3ccccc31)CCN1C[C@@H]3CCCC[C@H]3C[C@@H]21

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Mimbane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SLC6A4 known ✓ P31645 2/20 0.47
ADRA1A known ✓ P35348 1/20 0.39
CYP1A2 P05177 1/20 0.41
CYP2D6 P10635 1/20 0.41
MCHR1 Q99705 3/20 0.38
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
HSD17B10 Q99714 2/20 0.37
ALDH1A1 P00352 1/20 0.37
HPGD P15428 1/20 0.37
KDM4E B2RXH2 1/20 0.36
ALOX15 P16050 1/20 0.36
MAPK1 P28482 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Mimbane SCHEMBL29658183 1.00 SLC6A4 (0.47) SLC6A4CYP1A2CYP2D6ADRA1AMCHR1
Mimbane SCHEMBL488924 0.99 SLC6A4 (0.48) SLC6A4CYP1A2CYP2D6ADRA1AMCHR1
SCHEMBL3857346 0.80 MCHR1 (0.52) SLC6A4CYP1A2CYP2D6ADRA1AMCHR1
SCHEMBL3858428 0.78 MCHR1 (0.52) SLC6A4CYP1A2CYP2D6ADRA1AMCHR1
SCHEMBL3867340 0.77 SLC6A4 (0.62) SLC6A4CYP1A2CYP2D6ADRA1A
SCHEMBL6672112 0.76 SLC6A4 (0.44) SLC6A4CYP1A2CYP2D6MCHR1MEN1
SCHEMBL3354675 0.73 ADRA2A (0.66) CYP1A2CYP2D6ADRA1AMEN1KMT2A
SCHEMBL1538791 0.71 CHRNA7 (0.62) CYP1A2CYP2D6ADRA1AMEN1KMT2A
SCHEMBL21307810 0.71 CHRNA7 (0.62) CYP1A2CYP2D6ADRA1AMEN1KMT2A
SCHEMBL29376699 0.71 CHRNA7 (0.62) CYP1A2CYP2D6ADRA1AMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 846 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240200072-A1 Allogeneic Cartilage Regeneration Tarachon, LLC (US) 2024-06-20 US claimed
US-9566349-B2 Intestinal peptide targeting ligands RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2017-02-14 US claimed
US-20160022820-A1 TRANSDERMAL DELIVERY SYSTEM ACRUX DDS PTY LTD. (AU) 2016-01-28 US claimed
US-8268352-B2 Modified release composition for highly soluble drugs TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-18 US claimed
US-8263125-B2 Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-11 US claimed
US-20080014272-A1 Compositions and Methods for Treatment of Chronic Pain Conditions DOV PHARMACEUTICAL, INC. 2008-01-17 US claimed
WO-2008008474-A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CHRONIC PAIN CONDITIONS DOV PHARMACEUTICAL, INC. (US) 2008-01-17 WO claimed
EP-1807071-A4 ANTIPYRETIC COMPOSITIONS AND METHODS DOV PHARMACEUTICAL INC (US) 2008-01-09 EP claimed
EP-1807071-A2 ANTIPYRETIC COMPOSITIONS AND METHODS DOV Pharmaceutical Inc. (US) 2007-07-18 EP claimed
US-20060100263-A1 Antipyretic compositions and methods DOV PHARMACEUTICAL, INC. 2006-05-11 US claimed
WO-2006050520-A2 ANTIPYRETIC COMPOSITIONS AND METHODS DOV PHARMACEUTICAL, INC. (US) 2006-05-11 WO claimed
US-20060024365-A1 Novel dosage form VAYA NAVIN 2006-02-02 US claimed
US-20060018933-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-20060018934-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
EP-3958767-B1 DEVICES FOR DELIVERING THERAPEUTIC MATERIALS TO THE INTERVERTEBRAL DISC WARSAW ORTHOPEDIC INC (US) 2026-04-22 EP disclosed
EP-4719353-A1 REVERSIBLE SURFACTANT AND MULTIFUNCTIONAL DRUG DELIVERY SYSTEMS BASED THEREON Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. (IL) 2026-04-08 EP disclosed
US-12582455-B2 Bone material dispensing device WARSAW ORTHOPEDIC, INC. (US) 2026-03-24 US disclosed
US-4440777-A ANTIINFLAMMATORY AGENTS; ANESTHETICS; ADRENERGIC BLOCKING AGENTS; COSMETICS MERCK & CO., INC. (US) 1984-04-03 US disclosed
EP-0069385-A2 Use of eucalyptol for enhancing skin permeation of bioaffecting agents MERCK & CO. INC. (US) 1983-01-12 EP disclosed
EP-0036138-A2 Composition of matter for topical application comprising a bio-affecting agent and N,N-diethyl-m-toluamide MERCK & CO. INC. (US) 1981-09-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160022820-A1 TRANSDERMAL DELIVERY SYSTEM S100A10, MMP20, TLR6 SLC6A4 217/4885ADRA1A 2060/4885CYP1A2 595/4885
US-20060100263-A1 Antipyretic compositions and methods GABRE, HTR5A, TPH2 SLC6A4 673/4885ADRA1A 870/4885CYP1A2 335/4885
US-12582455-B2 Bone material dispensing device BMP2, BMP4, BMP1 SLC6A4 976/4885ADRA1A 4595/4885CYP1A2 4738/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.