Hydrochloric Acid

Hydrochloric Acid

SCHEMBL20239294

COC(=O)c1cc2cc(NC(=O)c3cc(N)cn3C)ccc2s1.Cl

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HDAC1 known ✓ Q13547 4/20 0.43
PDGFRB known ✓ P09619 9/20 0.41
KDR known ✓ P35968 9/20 0.41
MEN1 O00255 2/20 0.46
MAPT P10636 2/20 0.46
KMT2A Q03164 2/20 0.46
PTPN2 P17706 1/20 0.38
KDM4E B2RXH2 1/20 0.38
ALDH1A1 P00352 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
RXFP1 Q9HBX9 1/20 0.37
BACE1 P56817 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18574511 0.99 MEN1 (0.47) MEN1MAPTKMT2AHDAC1PDGFRB
SCHEMBL26725195 0.87 MAPT (0.53) MEN1MAPTKMT2AHDAC1PDGFRB
SCHEMBL18314056 0.85 MEN1 (0.46) MEN1MAPTKMT2AHDAC1PDGFRB
SCHEMBL18976114 0.84 HPGD (0.49) MAPTKMT2AHDAC1KDM4EALDH1A1
SCHEMBL22824708 0.83 HDAC1 (0.41) MAPTHDAC1PDGFRBKDRKDM4E
Hydrochloric Acid SCHEMBL20239286 0.82 MEN1 (0.45) MEN1MAPTKMT2AHDAC1PDGFRB
SCHEMBL18314047 0.82 LEF1 (0.44) MEN1MAPTKMT2AHDAC1PDGFRB
SCHEMBL26374378 0.81 RAB9A (0.43) HDAC1KDM4E
SCHEMBL22272502 0.81 HDAC1 (0.52) MEN1MAPTKMT2AHDAC1PDGFRB
SCHEMBL22824716 0.79 HDAC1 (0.39) HDAC1BACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12583857-B2 Anti-liferative agents comprising substituted benzo[e]pyrido[1,2-a][1,4]diazepines PHEON THERAPEUTICS LTD (GB) 2026-03-24 US disclosed
US-20250011317-A1 ANTI-PROLIFERATIVE AGENTS PHEON THERAPEUTICS LTD (GB) 2025-01-09 US disclosed
US-11912700-B2 Anti-proliferative agents comprising substituted benzo[e]pyrido[1,2-a][1,4]diazepines PHEON THERAPEUTICS LTD (GB) 2024-02-27 US disclosed
EP-4086251-A1 PIPERIDINOBENZODIAZEPINE COMPOUNDS WITH ANTI PROLIFERATIVE ACTIVITY Femtogenix Limited (GB) 2022-11-09 EP disclosed
CN-114907345-A Piperidine-benzodiazepine compound having anti-proliferative activity 福姆通格尼克斯有限公司 2022-08-16 CN disclosed
EP-3337795-B1 PIPERIDINOBENZODIAZEPINE COMPOUNDS WITH ANTI PROLIFERATIVE ACTIVITY FEMTOGENIX LTD (GB) 2022-06-22 EP disclosed
US-20210371413-A1 POLYCYCLIC AMIDES AS CYTOTOXIC AGENTS Pheon Therapeutics Ltd. (GB) 2021-12-02 US disclosed
US-20210206763-A1 Anti-Proliferative Agents PHEON THERAPEUTICS LTD (GB) 2021-07-08 US disclosed
US-10975072-B2 Substituted 6a,7,8,9,10,12-hexahydrobenzo[e]pyrido[1,2-a][1,4]diazepines as anti-proliferative agents FEMTOGENIX LIMITED 2021-04-13 US disclosed
US-10975074-B2 Anti-liferative agents comprising substituted benzo[e]pyrido[1,2-a][1,4]diazepines FEMTOGENIX LIMITED 2021-04-13 US disclosed
US-20190308970-A1 ANTI-LIFERATIVE AGENTS COMPRISING SUBSTITUTED PYRROLO-, INDOLINO- OR TETRAHYDROISOQUINOLINE-BENZODIAZEPINES PHEON THERAPEUTICS LTD (GB) 2019-10-10 US disclosed
US-10399970-B2 Pyrridinobenzodiazepine and benzopyrridodiazecine compounds FEMTOGENIX LIMITED (GB) 2019-09-03 US disclosed
US-20180339985-A1 PDD COMPOUNDS FEMTOGENIX LIMITED (GB) 2018-11-29 US disclosed
US-20180291021-A1 PDD COMPOUNDS PHEON THERAPEUTICS LTD (GB) 2018-10-11 US disclosed
US-20180162855-A1 PDD AND BPD COMPOUNDS PHEON THERAPEUTICS LTD (GB) 2018-06-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210371413-A1 POLYCYCLIC AMIDES AS CYTOTOXIC AGENTS PBRM1, NFATC1, ACIN1 HDAC1 349/4885PDGFRB 3084/4885KDR 1773/4885
US-20210206763-A1 Anti-Proliferative Agents CCND2, BRD2, DRD2 HDAC1 262/4885PDGFRB 2035/4885KDR 4258/4885
US-10975074-B2 Anti-liferative agents comprising substituted benzo[e]pyrido[1,2-a][1,4]diazepines CNR1, GABRA1, BAK1 HDAC1 90/4885PDGFRB 652/4885KDR 4246/4885
US-10399970-B2 Pyrridinobenzodiazepine and benzopyrridodiazecine compounds DRD1, XDH, DRD2 HDAC1 1110/4885PDGFRB 3771/4885KDR 3111/4885
US-12583857-B2 Anti-liferative agents comprising substituted benzo[e]pyrido[1,2-a][1,4]diazepines CNR1, MTNR1B, MTNR1A HDAC1 147/4885PDGFRB 1891/4885KDR 3268/4885
US-20250011317-A1 ANTI-PROLIFERATIVE AGENTS CCND2, BRD2, CCND3 HDAC1 270/4885PDGFRB 1585/4885KDR 4059/4885
US-10975072-B2 Substituted 6a,7,8,9,10,12-hexahydrobenzo[e]pyrido[1,2-a][1,4]diazepines as anti-proliferative agents PDCD1, CCND1, PDCD6 HDAC1 658/4885PDGFRB 211/4885KDR 2485/4885
US-20190308970-A1 ANTI-LIFERATIVE AGENTS COMPRISING SUBSTITUTED PYRROLO-, INDOLINO- OR TETRAHYDROISOQUINOLINE-BENZODIAZEPINES GABRA1, GABBR1, GABRA2 HDAC1 232/4885PDGFRB 684/4885KDR 4306/4885
US-20180291021-A1 PDD COMPOUNDS DRD1, DRD3, DRD2 HDAC1 1205/4885PDGFRB 1988/4885KDR 3473/4885
US-20180162855-A1 PDD AND BPD COMPOUNDS DRD1, DRD2, XDH HDAC1 1198/4885PDGFRB 3538/4885KDR 3243/4885
US-11912700-B2 Anti-proliferative agents comprising substituted benzo[e]pyrido[1,2-a][1,4]diazepines MKI67, CCND2, CCND1 HDAC1 301/4885PDGFRB 214/4885KDR 2855/4885
US-20180339985-A1 PDD COMPOUNDS DRD1, DRD3, DRD2 HDAC1 1085/4885PDGFRB 2265/4885KDR 3640/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.