Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 known ✓ | P50406 | 5/20 | 0.97 |
| ▸ | HTR7 known ✓ | P34969 | 5/20 | 0.97 |
| ▸ | HTR1D known ✓ | P28221 | 4/20 | 0.97 |
| ▸ | HTR3A known ✓ | P46098 | 2/20 | 0.97 |
| ▸ | HTR2B known ✓ | P41595 | 3/20 | 0.51 |
| ▸ | HTR1A known ✓ | P08908 | 3/20 | 0.51 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.51 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.51 |
| ▸ | HTR1E known ✓ | P28566 | 2/20 | 0.49 |
| ▸ | HTR5A known ✓ | P47898 | 2/20 | 0.49 |
| ▸ | HTR3E known ✓ | A5X5Y0 | 1/20 | 0.49 |
| ▸ | HTR3B known ✓ | O95264 | 1/20 | 0.49 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.49 |
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.49 |
| ▸ | HTR1F known ✓ | P30939 | 1/20 | 0.49 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.49 |
| ▸ | SLC18A2 known ✓ | Q05940 | 1/20 | 0.49 |
| ▸ | HTR4 known ✓ | Q13639 | 1/20 | 0.49 |
| ▸ | HTR3D known ✓ | Q70Z44 | 1/20 | 0.49 |
| ▸ | HTR3C known ✓ | Q8WXA8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29361176 | 0.98 | HTR6 (1.00) | HTR6HTR7HTR1DCYP1A2CYP3A4 | |
| SCHEMBL399028 | 0.98 | HTR6 (1.00) | HTR6HTR7HTR1DCYP1A2CYP3A4 | |
| Fumaric Acid SCHEMBL1320838 | 0.88 | NPSR1 (1.00) | HTR6HTR7HTR1DCYP1A2CYP3A4 | |
| Maleic Acid SCHEMBL1320833 | 0.88 | NPSR1 (1.00) | HTR6HTR7HTR1DCYP1A2CYP3A4 | |
| Serotonin SCHEMBL27310578 | 0.87 | HTR1D (0.78) | HTR6HTR7HTR1DCYP1A2CYP3A4 | |
| SCHEMBL21374161 | 0.84 | HTR7 (0.74) | HTR6HTR7HTR1DCYP1A2CYP3A4 | |
| SCHEMBL7886752 | 0.82 | HTR1D (0.71) | HTR6HTR7HTR1DCYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL21546038 | 0.81 | HTR6 (0.66) | HTR6HTR7HTR1DCYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL4659167 | 0.81 | HTR6 (0.66) | HTR6HTR7HTR1DCYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL892350 | 0.81 | HTR6 (0.67) | HTR6HTR7HTR1DCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660079-A2 | COMPOSITIONS OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND A SEROTONIN MODULATING AGENT FOR THE TREATMENT OF NEOPLASIA | Pharmacia Corporation (US) | 2006-05-31 | — | — | EP | claimed |
| US-20050085477-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and a serotonin-modulating agent for the treatment of neoplasia | PHARMACIA CORPORATION | 2005-04-21 | — | — | US | claimed |
| WO-2005018569-A2 | COMPOSITIONS OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND A SEROTONIN MODULATING AGENT FOR THE TREATMENT OF NEOPLASIA | PHARMACIA CORPORATION (US) | 2005-03-03 | — | — | WO | claimed |
| US-12180509-B2 | Methods for reprograming non-pluripotent cells into pluripotent stem cells | BEIHAO STEM CELL AND REGENERATIVE MEDICINE RESEARCH INSTITUTE CO., LTD. (CN) | 2024-12-31 | — | — | US | disclosed |
| EP-3384007-B1 | IMPROVED METHODS FOR REPROGRAMING NON-PLURIPOTENT CELLS INTO PLURIPOTENT STEM CELLS | BEIHAO STEM CELL AND REGENERATIVE MEDICINE RES INSTITUTE CO LTD (CN) | 2024-03-27 | — | — | EP | disclosed |
| CN-111050800-B | Treatment of pain with serotonin 3 receptor agonists | 国立大学法人大阪大学 | 2023-04-04 | — | — | CN | disclosed |
| US-11446290-B2 | Treatment of pain with serotonin-3 receptor agonist | OSAKA UNIVERSITY (JP) | 2022-09-20 | — | — | US | disclosed |
| US-20220025321-A1 | METHODS FOR REPROGRAMING NON-PLURIPOTENT CELLS INTO PLURIPOTENT STEM CELLS | HONG GUAN LTD. (CN) | 2022-01-27 | — | — | US | disclosed |
| US-20210145814-A1 | TREATMENT OF PAIN WITH SEROTONIN-3 RECEPTOR AGONIST | OSAKA UNIVERSITY (JP) | 2021-05-20 | — | — | US | disclosed |
| EP-3646886-A1 | TREATMENT OF PAIN WITH SEROTONIN-3 RECEPTOR AGONIST | Osaka University (JP) | 2020-05-06 | — | — | EP | disclosed |
| CN-111050800-A | Treatment of pain with serotonin 3 receptor agonists | 国立大学法人大阪大学 | 2020-04-21 | — | — | CN | disclosed |
| EP-1423006-A4 | AGONISTS AND ANTAGONISTS OF 5H 3?-LIKE RECEPTORS OF INVERTEBRATE S AS PESTICIDES | COMMW SCIENT IND RES ORG (AU) | 2006-02-01 | — | — | EP | disclosed |
| CN-1638633-A | Agonists and antagonists of 5h3-like receptors of invertebrates as pesticides | COMMW SCIENT IND RES ORG (AU) | 2005-07-13 | — | — | CN | disclosed |
| US-20050085477-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and a serotonin-modulating agent for the treatment of neoplasia | PHARMACIA CORPORATION | 2005-04-21 | — | — | US | disclosed |
| US-20050080084-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and a serotonin-modulating agent for the treatment of central nervous system damage | PHARMACIA CORPORATION | 2005-04-14 | — | — | US | disclosed |
| US-20050054680-A1 | Agonists and antagonists of 5h3-like receptors of invertebrates as pesticides | COMMONWEALTH SCIENTIFIC INDUSTRIAL RESEARCH ORGANISATION (AU) | 2005-03-10 | — | — | US | disclosed |
| WO-2005018541-A2 | COX-2 INHIBITOR AND SEROTONIN MODULATOR FOR TREATING CNS DAMAGE | PHARMACIA CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |
| WO-2005018569-A2 | COMPOSITIONS OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND A SEROTONIN MODULATING AGENT FOR THE TREATMENT OF NEOPLASIA | PHARMACIA CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |
| EP-1423006-A1 | AGONISTS AND ANTAGONISTS OF 5H 3?-LIKE RECEPTORS OF INVERTEBRATE S AS PESTICIDES | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003015517-A1 | AGONISTS AND ANTAGONISTS OF 5H3-LIKE RECEPTORS OF INVERTEBRATE S AS PESTICIDES | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2003-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050085477-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and a serotonin-modulating agent for the treatment of neoplasia | TPH2, TPH1, HTR2A | HTR6 10/4885HTR7 19/4885HTR1D 35/4885 |
| US-20050080084-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and a serotonin-modulating agent for the treatment of central nervous system damage | TPH2, TPH1, HTR2A | HTR6 11/4885HTR7 25/4885HTR1D 46/4885 |
| US-20220025321-A1 | METHODS FOR REPROGRAMING NON-PLURIPOTENT CELLS INTO PLURIPOTENT STEM CELLS | AHCY, BHMT, SHMT1 | HTR6 1984/4885HTR7 2384/4885HTR1D 3639/4885 |
| US-11446290-B2 | Treatment of pain with serotonin-3 receptor agonist | HTR3A, HTR3C, HTR3B | HTR6 20/4885HTR7 14/4885HTR1D 7/4885 |
| US-20050054680-A1 | Agonists and antagonists of 5h3-like receptors of invertebrates as pesticides | HTR3C, HTR3A, HTR3E | HTR6 18/4885HTR7 13/4885HTR1D 10/4885 |
| US-20210145814-A1 | TREATMENT OF PAIN WITH SEROTONIN-3 RECEPTOR AGONIST | HTR3A, HTR3C, HTR3B | HTR6 20/4885HTR7 14/4885HTR1D 7/4885 |
| US-12180509-B2 | Methods for reprograming non-pluripotent cells into pluripotent stem cells | AHCY, BHMT, SHMT1 | HTR6 1984/4885HTR7 2384/4885HTR1D 3639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.