SCHEMBL55916

SCHEMBL55916

O=C(CO)c1ccc(Br)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 3/20 0.67
HDAC1 Q13547 3/20 0.61
HDAC8 Q9BY41 3/20 0.61
HDAC3 O15379 1/20 0.61
HDAC4 P56524 1/20 0.61
HDAC7 Q8WUI4 1/20 0.61
HDAC2 Q92769 1/20 0.61
HDAC10 Q969S8 1/20 0.61
HDAC11 Q96DB2 1/20 0.61
HDAC6 Q9UBN7 1/20 0.61
HDAC9 Q9UKV0 1/20 0.61
HDAC5 Q9UQL6 1/20 0.61
CES2 O00748 1/20 0.56
CES1 P23141 1/20 0.56
CA1 P00915 2/20 0.52
CA2 P00918 2/20 0.52
OGG1 O15527 1/20 0.52
HAO1 Q9UJM8 1/20 0.52
NPC1 O15118 1/20 0.48
HPGD P15428 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30694356 0.87 KDM4E (0.50) GSK3BHDAC1HDAC8HDAC3HDAC4
SCHEMBL1305020 0.82 GSK3B (0.70) GSK3BHDAC1HDAC8HDAC3HDAC4
SCHEMBL241664 0.82 GSK3B (0.70) GSK3BHDAC1HDAC8HDAC3HDAC4
SCHEMBL25894500 0.81 ALDH1A1 (0.65) GSK3BHDAC1HDAC8HDAC3HDAC4
SCHEMBL15348715 0.81 GSK3B (0.55) GSK3BHDAC1HDAC8HDAC3HDAC4
SCHEMBL9909658 0.80 GSK3B (0.67) GSK3BHDAC1HDAC8HDAC3HDAC4
SCHEMBL70930 0.80 GSK3B (1.00) GSK3BHDAC1HDAC8HDAC3HDAC4
SCHEMBL3469826 0.80 GSK3B (0.71) GSK3BHDAC1HDAC8HDAC3HDAC4
SCHEMBL301099 0.78 GSK3B (0.64) GSK3BHDAC1HDAC8HDAC3HDAC4
SCHEMBL301100 0.78 GSK3B (0.64) GSK3BHDAC1HDAC8HDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 265 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116178385-B Coumarin hemicyanine dye with structural rigidity, and preparation method and application thereof 山西大学 2025-01-28 CN claimed
CN-114835698-B (diphenylamino) phenyl flavonoid fluorescent probe for detecting cysteine and preparation method thereof 南京林业大学 2024-03-15 CN claimed
CN-114751870-B 2- (isoxazole-5-yl) phenyl-3, 4-dihydroxybenzoate and derivative thereof, and synthetic method and application thereof 贵州医科大学 2023-10-20 CN claimed
CN-116515782-A Amine dehydrogenase mutant and application thereof in chiral amine alcohol compound synthesis 中国科学院天津工业生物技术研究所 2023-08-01 CN claimed
CN-116178385-A Coumarin hemicyanine dye with structural rigidity, and preparation method and application thereof 山西大学 2023-05-30 CN claimed
CN-114146071-B Application of paeonol and its derivatives in preventing and treating leukoplakia syndrome 西北农林科技大学深圳研究院 2023-02-28 CN claimed
CN-114835698-A (diphenylamino) phenyl flavonoid fluorescent probe for detecting cysteine and preparation method thereof 南京林业大学 2022-08-02 CN claimed
CN-114751870-A 2- (isoxazole-5-yl) phenyl-3, 4-dihydroxy benzoate and derivative thereof, and synthesis method and application thereof 贵州医科大学 2022-07-15 CN claimed
CN-114146071-A Application of paeonol and its derivatives in preventing and treating leukoplakia syndrome 西北农林科技大学深圳研究院 2022-03-08 CN claimed
CN-111233801-B Colorimetric probe for rapidly detecting solvent components and preparation method and application thereof 北京师范大学 2021-09-07 CN claimed
CN-111548280-B Fluorescent probe for rapidly identifying mercury and methyl mercury as well as preparation method and application thereof 北京师范大学 2021-04-20 CN claimed
CN-108484511-A A kind of ligustrazine chalcone compounds and its preparation method and application 山东大学 2018-09-04 CN claimed
CN-106008475-A Coumarin NEDD8 activating enzyme inhibitor 南京工业大学 2016-10-12 CN claimed
CN-104560745-A Pichia sp.SIT2014 and culture method and application thereof SHANGHAI INST TECHNOLOGY 2015-04-29 CN claimed
US-20120029226-A1 METHOD FOR THE SYNTHESIS OF CHIRAL ALPHA-ARYL PROPIONIC ACID DERIVATIVES DSM IP ASSETS B.V. (NL) 2012-02-02 US claimed
EP-2393771-A1 Method for the synthesis of chiral alpha-aryl propionic acid derivatives DSM IP Assets B.V. (NL) 2011-12-14 EP claimed
WO-2010089343-A1 METHOD FOR THE SYNTHESIS OF CHIRAL ALPHA-ARYL PROPIONIC ACID DERIVATIVES DSM IP ASSETS B.V. (NL) 2010-08-12 WO claimed
CN-101580445-A Method for microwave synthesis of alpha-hydroxyacetophenone series compounds UNIV JIANGNAN (CN) 2009-11-18 CN claimed
US-4067866-A Process for preparing cephalosporins and certain novel 2β-thiohydrazo-azetidinones as intermediates SOCIETA' FARMACEUTICI ITALIA (IT) 1978-01-10 US claimed
US-20260041671-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS INC (US) 2026-02-12 US disclosed
US-12539292-B2 BRM targeting compounds and associated methods of use ARVINAS OPERATIONS, INC. (US) 2026-02-03 US disclosed
US-12312316-B2 Compounds and methods for the targeted degradation of androgen receptor ARVINAS OPERATIONS, INC. (US) 2025-05-27 US disclosed
WO-2025103442-A1 SUBSTITUTED 2-(PYRROLIDIN-3-YL)ACETIC ACID DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF 上海翊石医药科技有限公司 2025-05-22 WO disclosed
EP-4537905-A2 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE Arvinas Operations, Inc. (US) 2025-04-16 EP disclosed
EP-3774789-B1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS INC (US) 2025-03-05 EP disclosed
CN-119371410-A Chromone spiro compound and preparation method and application thereof 中国药科大学 2025-01-28 CN disclosed
CN-116178385-B Coumarin hemicyanine dye with structural rigidity, and preparation method and application thereof 山西大学 2025-01-28 CN disclosed
US-12172989-B2 Histone acetyltransferase (HAT) inhibitor and use thereof SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) 2024-12-24 US disclosed
CN-118812521-A Benzo heterocyclic compound and application thereof 中科中山药物创新研究院 2024-10-22 CN disclosed
WO-2024179529-A1 SUBSTITUTED TRICYCLIC DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF 上海海雁医药科技有限公司 2024-09-06 WO disclosed
CN-118140931-A Application of chromene-thiazole/oxazolamine compound 贵州医科大学 2024-06-07 CN disclosed
CN-117858877-A C-linked inhibitors of ENL/AF9 YEATS 桥梁药品有限公司 2024-04-09 CN disclosed
CN-114805224-B Ligustrazine chalcone derivative and preparation method and application thereof 山东大学 2024-03-22 CN disclosed
CN-115806493-B Method for synthesizing epstein chiral intermediate by asymmetric hydrogenation 南京工业大学 2024-03-22 CN disclosed
CN-114835698-B (diphenylamino) phenyl flavonoid fluorescent probe for detecting cysteine and preparation method thereof 南京林业大学 2024-03-15 CN disclosed
CN-114835698-B (diphenylamino) phenyl flavonoid fluorescent probe for detecting cysteine and preparation method thereof 南京林业大学 2024-03-15 CN disclosed
CN-117683026-A 3-tetrahydrofuran chromone compound and diastereoisomeric divergent preparation method and application thereof 广州中医药大学(广州中医药研究院) 2024-03-12 CN disclosed
US-20240076295-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE GENENTECH, INC. 2024-03-07 US disclosed
CN-114105753-B Fisetin derivative and application thereof in preparation of anti-inflammatory drugs 温州医科大学 2024-02-20 CN disclosed
CN-117164845-B Preparation method and application of polymethine nanocluster 吉林大学第一医院 2024-02-09 CN disclosed
CN-113999223-B Thiazole-containing flavonoid derivative, preparation method and application thereof 扬州大学 2023-12-19 CN disclosed
WO-2023234187-A1 METHOD FOR PRODUCING ORGANIC COPPER COMPOUND シンクレスト株式会社 2023-12-07 WO disclosed
CN-117164845-A Preparation method and application of polymethine nanocluster 吉林大学第一医院 2023-12-05 CN disclosed
EP-3782995-B1 SPIRO CONDENSED IMIDAZOLINE-2,4-DIONE DERIVATIVES AS HISTONE ACETYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF CANCER DISEASES SHANGHAI INST MATERIA MEDICA CAS (CN) 2023-11-22 EP disclosed
CN-114751870-B 2- (isoxazole-5-yl) phenyl-3, 4-dihydroxybenzoate and derivative thereof, and synthetic method and application thereof 贵州医科大学 2023-10-20 CN disclosed
CN-116515782-A Amine dehydrogenase mutant and application thereof in chiral amine alcohol compound synthesis 中国科学院天津工业生物技术研究所 2023-08-01 CN disclosed
US-11701373-B2 Substituted bicyclic compounds BRISTOL-MYERS SQUIBB COMPANY (US) 2023-07-18 US disclosed
CN-114057626-B Indole-2, 3-dione derivative, preparation method thereof and anti-liver cancer drug for inhibiting RECQL4 specific expression 山东第一医科大学(山东省医学科学院) 2023-06-30 CN disclosed
WO-2023120645-A1 ORGANIC ZINC COMPOUND AND PRODUCTION METHOD FOR ORGANIC ZINC COMPOUND シンクレスト株式会社 2023-06-29 WO disclosed
WO-2023120647-A1 ORGANIC COPPER COMPOUND, AND METHOD FOR PRODUCING ORGANIC COPPER COMPOUND シンクレスト株式会社 2023-06-29 WO disclosed
CN-116178385-A Coumarin hemicyanine dye with structural rigidity, and preparation method and application thereof 山西大学 2023-05-30 CN disclosed
CN-110950860-B Fused tricyclic compound and application thereof in medicines 广东东阳光药业有限公司 2023-03-31 CN disclosed
EP-3473639-B1 HEPATITIS C VIRUS INHIBITOR AND APPLICATION ZHEJIANG PALO ALTO PHARMACEUTICALS INC (CN) 2023-03-29 EP disclosed
CN-115806493-A Method for synthesizing chiral ebavir intermediate by asymmetric hydrogenation 南京工业大学 2023-03-17 CN disclosed
CN-114146071-B Application of paeonol and its derivatives in preventing and treating leukoplakia syndrome 西北农林科技大学深圳研究院 2023-02-28 CN disclosed
US-20220387615-A1 COMPOSITIONS COMPRISING ENZYME CLEAVABLE LINKER PLATFORMS AND CONJUGATES THEREOF DANMARKS TEKNISKE UNIVERSITET (DK) 2022-12-08 US disclosed
US-20220387615-A1 COMPOSITIONS COMPRISING ENZYME CLEAVABLE LINKER PLATFORMS AND CONJUGATES THEREOF DANMARKS TEKNISKE UNIVERSITET (DK) 2022-12-08 US disclosed
US-20220331346-A1 SUBSTITUTED BICYCLIC COMPOUNDS BRISTOL MYERS SQUIBB CO (US) 2022-10-20 US disclosed
CN-110386927-B Histone Acetyltransferase (HAT) inhibitors and uses thereof 中国科学院上海药物研究所 2022-09-23 CN disclosed
CN-115040497-A Application of paeonol derivative in preventing and treating leukoplakia syndrome 西北农林科技大学深圳研究院 2022-09-13 CN disclosed
CN-110773223-B g-C 3 N 4 Supported transition metal oxide and application thereof in synthesis of alpha-hydroxy ketone 南京理工大学 2022-09-09 CN disclosed
CN-115010688-A One-pot preparation method of 4-chromanone, congeners and derivatives thereof 烟台六谛医药科技有限公司 2022-09-06 CN disclosed
US-11427548-B2 Compounds and methods for the targeted degradation of androgen receptor ARVINAS OPERATIONS, INC. (US) 2022-08-30 US disclosed
EP-4038066-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE Arvinas Operations, Inc. (US) 2022-08-10 EP disclosed
CN-114835698-A (diphenylamino) phenyl flavonoid fluorescent probe for detecting cysteine and preparation method thereof 南京林业大学 2022-08-02 CN disclosed
CN-113135814-B Method for synthesizing chiral 1, 2-diol compound 温州大学 2022-08-02 CN disclosed
CN-114835698-A (diphenylamino) phenyl flavonoid fluorescent probe for detecting cysteine and preparation method thereof 南京林业大学 2022-08-02 CN disclosed
CN-114805224-A Ligustrazine chalcone derivative and preparation method and application thereof 山东大学 2022-07-29 CN disclosed
CN-114787159-A BRM targeting compounds and related methods of use 阿尔维纳斯运营股份有限公司 2022-07-22 CN disclosed
CN-114751870-A 2- (isoxazole-5-yl) phenyl-3, 4-dihydroxy benzoate and derivative thereof, and synthesis method and application thereof 贵州医科大学 2022-07-15 CN disclosed
EP-3990027-A1 COMPOSITIONS COMPRISING ENZYME CLEAVABLE LINKER PLATFORMS AND CONJUGATES THEREOF Danmarks Tekniske Universitet (DK) 2022-05-04 EP disclosed
CN-114146071-A Application of paeonol and its derivatives in preventing and treating leukoplakia syndrome 西北农林科技大学深圳研究院 2022-03-08 CN disclosed
CN-114105753-A Fisetin derivative and application thereof in preparation of anti-inflammatory drugs 温州医科大学 2022-03-01 CN disclosed
CN-114057626-A Indole-2, 3-dione derivative, preparation method thereof and anti-liver cancer drug for inhibiting RECQL4 specific expression 山东第一医科大学(山东省医学科学院) 2022-02-18 CN disclosed
CN-113999223-A Flavone derivative containing thiazole, preparation method and application thereof 扬州大学 2022-02-01 CN disclosed
CN-110511233-B Thiazolo [2,3-b ] oxazolone compound and preparation method and application thereof 成都大学 2022-01-25 CN disclosed
US-20220002278-A9 HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF SUZHOU INSTITUTE OF MATERIA MEDICA (CN) 2022-01-06 US disclosed
WO-2021238588-A1 OXATHIAZINE COMPOUND AND USE THEREOF 四川大学华西医院 2021-12-02 WO disclosed
CN-108558813-B Resveratrol derivative containing flavonoid as well as preparation method and application thereof 合肥工业大学 2021-07-23 CN disclosed
CN-113135814-A Method for synthesizing chiral 1, 2-diol compound 温州大学 2021-07-20 CN disclosed
US-11058696-B2 Substituted bicyclic compounds BRISTOL-MYERS SQUIBB COMPANY (US) 2021-07-13 US disclosed
CN-110066278-B Fused tricyclic compound and application thereof in medicines 广东东阳光药业有限公司 2021-06-08 CN disclosed
EP-3183242-B1 SUBSTITUTED BICYCLIC COMPOUNDS BRISTOL MYERS SQUIBB CO (US) 2021-05-19 EP disclosed
CN-109134481-B Substituted pyrrole chromone compound or pharmaceutically acceptable salt thereof, and preparation method and application thereof 中山大学 2021-05-14 CN disclosed
WO-2021067606-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. (US) 2021-04-08 WO disclosed
US-20210101891-A1 HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF SHANGHAI INST MATERIA MEDICA CAS (CN) 2021-04-08 US disclosed
WO-2021067606-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. (US) 2021-04-08 WO disclosed
CN-111518058-B Oxathiazine compound and application thereof 四川大学华西医院 2021-03-09 CN disclosed
EP-3782995-A1 HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) 2021-02-24 EP disclosed
CN-107522716-B Hepatitis C virus inhibitor and application thereof 浙江柏拉阿图医药科技有限公司 2021-02-02 CN disclosed
CN-112166114-A BRM targeting compounds and related methods of use 阿尔维纳斯运营股份有限公司 2021-01-01 CN disclosed
WO-2020260597-A1 COMPOSITIONS COMPRISING ENZYME CLEAVABLE LINKER PLATFORMS AND CONJUGATES THEREOF DANMARKS TEKNISKE UNIVERSITET (DK) 2020-12-30 WO disclosed
CN-108906053-B Hydrophobic hydrotalcite loaded bimetallic catalyst and oxidation catalysis application thereof 中国科学院兰州化学物理研究所苏州研究院 2020-11-03 CN disclosed
US-20200281952-A1 SUBSTITUTED BICYCLIC COMPOUNDS BRISTOL MYERS SQUIBB CO (US) 2020-09-10 US disclosed
EP-2972399-B1 LIPIDS THAT INCREASE INSULIN SENSITIVITY AND METHODS OF USING THE SAME BETH ISRAEL DEACONESS MEDICAL CT INC (US) 2020-09-02 EP disclosed
CN-111518058-A Oxathiazine compound and application thereof 四川大学华西医院 2020-08-11 CN disclosed
US-10709719-B2 Substituted bicyclic compounds BRISTOL-MYERS SQUIBB COMPANY (US) 2020-07-14 US disclosed
CN-107148409-B Substituted bicyclic compounds 百时美施贵宝公司 2020-07-10 CN disclosed
EP-3658548-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR Arvinas Operations, Inc. (US) 2020-06-03 EP disclosed
US-10640515-B2 Hepatitis C virus inhibitor and uses thereof ZHEJIANG PALO ALTO PHARMACEUTICALS, INC (CN) 2020-05-05 US disclosed
EP-3256468-B1 TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE SUNSHINE LAKE PHARMA CO LTD (CN) 2020-04-08 EP disclosed
CN-110950860-A Fused tricyclic compound and application thereof in medicines 广东东阳光药业有限公司 2020-04-03 CN disclosed
US-20200055825-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR Arvinas, Inc. 2020-02-20 US disclosed
CN-110773223-A g-C 3N 4Supported transition metal oxide and application thereof in synthesis of α -hydroxyketone 南京理工大学 2020-02-11 CN disclosed
US-20200038378-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE GENENTECH, INC. 2020-02-06 US disclosed
US-20200038378-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE GENENTECH, INC. 2020-02-06 US disclosed
CN-105884758-B Tricyclic compounds and their use in medicine 广东东阳光药业有限公司 2019-12-10 CN disclosed
WO-2019195201-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. (US) 2019-10-10 WO disclosed
US-20190300521-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE GENENTECH, INC. 2019-10-03 US disclosed
US-20190300521-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE GENENTECH, INC. 2019-10-03 US disclosed
CN-110015983-A 1,2- dicarbapentaborane class compound and its synthetic method 华东师范大学 2019-07-16 CN disclosed
US-20190135828-A1 HEPATITIS C VIRUS INHIBITOR AND USES THEREOF ZHEJIANG PALO ALTO PHARMACEUTICALS,INC (CN) 2019-05-09 US disclosed
EP-3473639-A1 HEPATITIS C VIRUS INHIBITOR AND APPLICATION Zhejiang Palo Alto Pharmaceuticals, Inc (CN) 2019-04-24 EP disclosed
US-20190076450-A1 SUBSTITUTED BICYCLIC COMPOUNDS BRISTOL MYERS SQUIBB CO (US) 2019-03-14 US disclosed
WO-2019023553-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR Arvinas, Inc. (US) 2019-01-31 WO disclosed
US-10183917-B2 Tricyclic compounds and uses thereof in medicine SUNSHINE LAKE PHARMA CO., LTD. (CN) 2019-01-22 US disclosed
CN-109134481-A A kind of substituted azole chromogen ketone compounds or its pharmaceutically acceptable salt and its preparation method and application 中山大学 2019-01-04 CN disclosed
US-10166249-B2 Substituted bicyclic compounds BRISTOL-MYERS SQUIBB COMPANY (US) 2019-01-01 US disclosed
CN-108906053-A Hydrophobic water talcum supported bimetal catalyst and its oxidation catalysis application 中国科学院兰州化学物理研究所苏州研究院 2018-11-30 CN disclosed
CN-108484511-A A kind of ligustrazine chalcone compounds and its preparation method and application 山东大学 2018-09-04 CN disclosed
WO-2018140809-A1 MODULATORS OF ESTROGEN RECEPTOR PROTEOLYSIS AND ASSOCIATED METHODS OF USE Arvinas, Inc. (US) 2018-08-02 WO disclosed
US-9981008-B2 Apolipoprotein A-I mimics CERENIS THERAPEUTICS HOLDING SA (FR) 2018-05-29 US disclosed
US-20180030003-A1 TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE SUNSHINE LAKE PHARMA CO., LTD. (CN) 2018-02-01 US disclosed
EP-3256468-A1 TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE Sunshine Lake Pharma Co., Ltd. (CN) 2017-12-20 EP disclosed
CN-104560745-B A kind of Pichia yeast Pichia sp.SIT2014 and its cultural method and application 上海应用技术学院 2017-12-01 CN disclosed
US-20170327469-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR ARVINAS OPERATIONS, INC. 2017-11-16 US disclosed
US-20170327469-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR ARVINAS OPERATIONS, INC. 2017-11-16 US disclosed
US-20170327469-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR ARVINAS OPERATIONS, INC. 2017-11-16 US disclosed
US-20170304332-A1 SUBSTITUTED BICYCLIC COMPOUNDS BRISTOL MYERS SQUIBB CO (US) 2017-10-26 US disclosed
US-9770459-B2 Substituted bicyclic compounds BRISTOL-MYERS SQUIBB COMPANY (US) 2017-09-26 US disclosed
US-20170042917-A1 SUBSTITUTED BICYCLIC COMPOUNDS BRISTOL MYERS SQUIBB CO (US) 2017-02-16 US disclosed
US-20170038642-A1 ALIGNMENT LAYER AND LIQUID CRYSTAL DISPLAY INCLUDING THE SAME SAMSUNG DISPLAY CO., LTD. (KR) 2017-02-09 US disclosed
EP-2939683-B1 Apolipoprotein A-I Mimics CERENIS THERAPEUTICS HOLDING SA (FR) 2017-01-04 EP disclosed
US-9522888-B2 Substituted bicyclic compounds BRISTOL-MYERS SQUIBB COMPANY (US) 2016-12-20 US disclosed
US-20160324923-A1 APOLIPOPROTEIN A-I MIMICS CERENIS THERAPEUTICS HOLDING SA (FR) 2016-11-10 US disclosed
CN-106008475-A Coumarin NEDD8 activating enzyme inhibitor 南京工业大学 2016-10-12 CN disclosed
WO-2016127924-A1 TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE SUNSHINE LAKE PHARMA CO., LTD. (CN) 2016-08-18 WO disclosed
US-9388232-B2 Apolipoprotein A-I mimics CERENIS THERAPEUTICS HOLDING SA (FR) 2016-07-12 US disclosed
US-20160185763-A1 LIQUID CRYSTAL STABILIZER, LIQUID CRYSTAL COMPOSITION INCLUDING THE SAME, AND LIQUID CRYSTAL DISPLAY INCLUDING THE SAME SAMSUNG DISPLAY CO., LTD. (KR) 2016-06-30 US disclosed
US-20160052888-A1 SUBSTITUTED BICYCLIC COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY 2016-02-25 US disclosed
WO-2014082379-A9 SPIRO RING COMPOUND AS HEPATITIS C VIRUS (HCV) INHIBITOR AND USES THEREOF FIELD OF THE INVENTION SUNSHINE LAKE PHARMA CO.,LTD. (CN) 2016-02-25 WO disclosed
CN-105051036-A Flavonoid or isoflavone compound and application thereof SHANGHAI ZHENGJI PHARMACEUTICALS CO LTD 2015-11-11 CN disclosed
EP-2939683-A1 Apolipoprotein A-I Mimics Cerenis Therapeutics Holding SA (FR) 2015-11-04 EP disclosed
WO-2015162538-A1 HETEROCYCLIC COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS FOR THE TREATMENT OF HYPERPARATHYROIDISM, CHRONIC RENAL FAILURE AND CHRONIC KIDNEY DISEASE LUPIN LIMITED (IN) 2015-10-29 WO disclosed
CN-103059042-B Thiophene derivants and the purposes in pharmacy thereof GINKGO PHARMACEUTICAL (SUZHOU) CO., LTD. (CN) 2015-10-07 CN disclosed
CN-104817483-A Bis carbonyl indole compound and synthesis method UNIV EAST CHINA NORMAL 2015-08-05 CN disclosed
EP-2396017-B1 APOLIPOPROTEIN A-I MIMICS CERENIS THERAPEUTICS HOLDING SA (FR) 2015-07-01 EP disclosed
US-20150141330-A1 APOLIPOPROTEIN A-I MIMICS CERENIS THERAPEUTICS HOLDING SA (FR) 2015-05-21 US disclosed
CN-103408414-B Preparation method of 2-hydroxyl-4-substituted arone compound BEIJING GREENCHEM TECHNOLOGY CO LTD 2015-05-13 CN disclosed
CN-104560745-A Pichia sp.SIT2014 and culture method and application thereof SHANGHAI INST TECHNOLOGY 2015-04-29 CN disclosed
US-8993597-B2 Apolipoprotein A-I mimics CERENIS THERAPEUTICS HOLDING SA (FR) 2015-03-31 US disclosed
CN-104177241-A Alkynyl diketone compound and synthetic method thereof UNIV EAST CHINA NORMAL 2014-12-03 CN disclosed
CN-103408414-A Preparation method of 2-hydroxyl-4-substituted arone compound BEIJING GREENCHEM TECHNOLOGY CO LTD 2013-11-27 CN disclosed
US-8541572-B2 Compounds for the treatment of inflammatory disorders MERCK SHARP & DOHME CORP. (US) 2013-09-24 US disclosed
US-8541572-B2 Compounds for the treatment of inflammatory disorders MERCK SHARP & DOHME CORP. (US) 2013-09-24 US disclosed
CN-103304571-A Spiro compound as well as preparation method, intermediate, pharmaceutical composition and application thereof SHANGHAI YUNYI HEALTH ADMINISTRATION CONSULTING CO LTD 2013-09-18 CN disclosed
US-20130231459-A1 APOLIPOPROTEIN A-I MIMICS CERENIS THERAPEUTICS HOLDING SA (FR) 2013-09-05 US disclosed
CN-103059042-A Thiophene derivative and application thereof to medicine GINKGO PHARMA CO LTD 2013-04-24 CN disclosed
US-8378068-B2 Apolipoprotein A-I mimics CERENIS THERAPEUTICS HOLDING SA (FR) 2013-02-19 US disclosed
US-20120289501-A1 Benzene-fused 6-membered oxygen-containing heterocyclic derivatives of bicyclic heteroaryls NOVARTIS AG (CH) 2012-11-15 US disclosed
EP-2504339-A1 BENZENE-FUSED 6-MEMBERED OXYGEN-CONTAINING HETEROCYCLIC DERIVATIVES OF BICYCLIC HETEROARYLS Novartis AG (CH) 2012-10-03 EP disclosed
CN-102712648-A Benzene-fused 6-membered oxygen-containing heterocyclic derivatives of bicyclic heteroaryls NOVARTIS AG 2012-10-03 CN disclosed
US-8263797-B2 Method for producing cyclopropane carboxylic acid compound and intermediate therefor SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-09-11 US disclosed
CN-102617585-A Furocoumarin derivative, preparation method thereof and use thereof SHANGHAI INST MATERIA MEDICA 2012-08-01 CN disclosed
US-8178559-B2 Organic compounds NOVARTIS AG (CH) 2012-05-15 US disclosed
US-8129411-B2 Organic compounds NOVARTIS AG (CH) 2012-03-06 US disclosed
EP-2420491-A1 3 , 5-substitued piperidine compounds as renin inhibitors Novartis AG (CH) 2012-02-22 EP disclosed
US-20120029226-A1 METHOD FOR THE SYNTHESIS OF CHIRAL ALPHA-ARYL PROPIONIC ACID DERIVATIVES DSM IP ASSETS B.V. (NL) 2012-02-02 US disclosed
US-20120010181-A1 COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS MERCK SHARP & DOHME CORP. 2012-01-12 US disclosed
US-20120010181-A1 COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS MERCK SHARP & DOHME CORP. 2012-01-12 US disclosed
US-8084450-B2 Organic compounds NOVARTIS AG (CH) 2011-12-27 US disclosed
EP-2393771-A1 Method for the synthesis of chiral alpha-aryl propionic acid derivatives DSM IP Assets B.V. (NL) 2011-12-14 EP disclosed
US-8076356-B2 Triazolopyridinylsulfanyl derivatives as P38 map kinase inhibitors PFIZER INC. (US) 2011-12-13 US disclosed
US-20110263560-A1 Organic Compounds NOVARTIS AG (CH) 2011-10-27 US disclosed
US-20110144080-A1 PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS ASTEX THERAPEUTICS LIMITED (GB) 2011-06-16 US disclosed
US-20110144080-A1 PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS ASTEX THERAPEUTICS LIMITED (GB) 2011-06-16 US disclosed
US-7960365-B2 Compounds with medicinal effects due to interaction with the glucocorticoid receptor N.V. ORGANON (NL) 2011-06-14 US disclosed
WO-2011064211-A1 BENZENE-FUSED 6-MEMBERED OXYGEN-CONTAINING HETEROCYCLIC DERIVATIVES OF BICYCLIC HETEROARYLS NOVARTIS AG (CH) 2011-06-03 WO disclosed
US-20100280267-A1 METHOD FOR PRODUCING CYCLOPROPANE CARBOXYLIC ACID COMPOUND AND INTERMEDIATE THEREFOR SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-11-04 US disclosed
EP-1951725-B1 N-SULFAMOYL-N -BENZOPYRANPIPERIDINES AS INHBITORS OF CARBONIC ANHYDRASES ABBOTT PRODUCTS GMBH (DE) 2010-11-03 EP disclosed
US-20100267631-A1 APOLIPOPROTEIN A-I MIMICS CERENIS THERAPEUTICS HOLDING SA (FR) 2010-10-21 US disclosed
EP-2241551-A1 METHOD FOR PRODUCING CYCLOPROPANE CARBOXYLIC ACID COMPOUND AND INTERMEDIATE THEREFOR Sumitomo Chemical Company, Limited (JP) 2010-10-20 EP disclosed
WO-2010117635-A1 HEPATITIS C VIRUS INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2010-10-14 WO disclosed
CN-101006087-B Triazolopyridinylsulfanyl derivatives as p38 MAP kinase inhibitors PFIZER 2010-09-29 CN disclosed
WO-2010089343-A1 METHOD FOR THE SYNTHESIS OF CHIRAL ALPHA-ARYL PROPIONIC ACID DERIVATIVES DSM IP ASSETS B.V. (NL) 2010-08-12 WO disclosed
WO-2010054279-A1 COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS SCHERING CORPORATION (US) 2010-05-14 WO disclosed
EP-2177518-A1 Organic compounds Novartis AG (CH) 2010-04-21 EP disclosed
US-20090312304-A1 ORGANIC COMPOUNDS NOVARTIS AG (CH) 2009-12-17 US disclosed
CN-101580445-A Method for microwave synthesis of alpha-hydroxyacetophenone series compounds UNIV JIANGNAN (CN) 2009-11-18 CN disclosed
EP-1833816-B1 SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS NOVARTIS AG (CH) 2009-11-11 EP disclosed
US-20090239899-A1 Triazolopyridinylsulfanyl Derivatives As P38 Map Kinase Inhibitors PFIZER INC. 2009-09-24 US disclosed
CN-101534811-A Compounds with medicinal effects due to interaction with the glucocorticoid receptor ORGANON NV (NL) 2009-09-16 CN disclosed
US-20090192148-A1 Organic Compounds NOVARTIS AG (CH) 2009-07-30 US disclosed
EP-1778686-B9 TRIAZOLOPYRIDINYLSULFANYL DERIVATIVES AS P38 MAP KINASE INHIBITORS PFIZER LTD (GB) 2009-07-08 EP disclosed
US-7547708-B2 N-sulfamoyl-N′-benzopyranpiperidine compounds and uses thereof SOLVAY PHARMACEUTICALS, INC. (DE) 2009-06-16 US disclosed
US-7511057-B2 Triazolopyridinylsulfanyl derivatives as p38 MAP kinase inhibitors PFIZER INC. (US) 2009-03-31 US disclosed
EP-1778686-B1 TRIAZOLOPYRIDINYLSULFANYL DERIVATIVES AS P38 MAP KINASE INHIBITORS PFIZER LTD (GB) 2008-10-29 EP disclosed
EP-1968940-A1 3 , 5-SUBSTITUED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS Novartis AG (CH) 2008-09-17 EP disclosed
EP-1965785-A1 COMPOUNDS WITH MEDICINAL EFFECTS DUE TO INTERACTION WITH THE GLUCOCORTICOID RECEPTOR N.V. Organon (NL) 2008-09-10 EP disclosed
EP-1951725-A1 N-SULFAMOYL-N -BENZOPYRANPIPERIDINES AS INHBITORS OF CARBONIC ANHYDRASES Solvay Pharmaceuticals GmbH (DE) 2008-08-06 EP disclosed
CN-101094848-A Organic compounds NOVARTIS AG (CH) 2007-12-26 CN disclosed
EP-1833816-A1 SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS Novartis AG (CH) 2007-09-19 EP disclosed
CN-101006087-A Triazolopyridinylsulfanyl derivatives as p38 MAP kinase inhibitors PFIZER (US) 2007-07-25 CN disclosed
WO-2007077005-A1 3 , 5-SUBSTITΓUED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS NOVARTIS AG (CH) 2007-07-12 WO disclosed
US-20070149577-A1 Compounds with medicinal effects due to interaction with the glucocorticoid receptor N.V. ORGANON (NL) 2007-06-28 US disclosed
WO-2007071638-A1 COMPOUNDS WITH MEDICINAL EFFECTS DUE TO INTERACTION WITH THE GLUCOCORTICOID RECEPTOR N.V. ORGANON (NL) 2007-06-28 WO disclosed
US-20070117823-A1 N-sulfamoyl-N'-benzopyranpiperidine compounds and uses thereof SOLVAY PHARMACEUTICALSS GMBH (DE) 2007-05-24 US disclosed
WO-2007054580-A1 N-SULFAMOYL-N’-BENZOPYRANPIPERIDINES AS INHBITORS OF CARBONIC ANHYDRASES SOLVAY PHARMACEUTICALS GMBH (DE) 2007-05-18 WO disclosed
EP-1778686-A2 TRIAZOLOPYRIDINYLSULFANYL DERIVATIVES AS P38 MAP KINASE INHIBITORS Pfizer Limited (GB) 2007-05-02 EP disclosed
WO-2006069788-A1 ORGANIC COMPOUNDS NOVARTIS AG (CH) 2006-07-06 WO disclosed
WO-2006018718-A2 TRIAZOLOPYRIDINYLSULFANYL DERIVATIVES AS P38 MAP KINASE INHIBITORS PFIZER LIMITED (GB) 2006-02-23 WO disclosed
US-20060035922-A1 Triazolopyridinylsulfanyl derivatives as p38 MAP kinase inhibitors PFIZER INC. 2006-02-16 US disclosed
US-20050256124-A1 Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto NEUROCRINE BIOSCIENCES, INC. (US) 2005-11-17 US disclosed
WO-2005103039-A1 2- (3-AMINOPYRROLIDIN-1-YL) PYRIDINES AS MELANIN-CONCENTRATING HORMONE RECEPTOR AN TAGONISTS NEUROCRINE BIOSCIENCES, INC. (US) 2005-11-03 WO disclosed
CN-1688549-A Compound having TGF-beta inhibitory activity and medicinal composition containing the same KIRIN BREWERY (JP) 2005-10-26 CN disclosed
CN-1182129-C Benzopyran derivatives having leukotriene-antagonistic action ������ʵ���ҹ�˾ 2004-12-29 CN disclosed
CN-1149196-C Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists ����˹�ж�-����˹˹������˾ 2004-05-12 CN disclosed
US-20040072871-A1 Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them WARNER-LAMBERT COMPANY LLC 2004-04-15 US disclosed
US-6703181-B1 COMPRISING AT LEAST ONE OF: IMIDAZOLE COMPOUND, AN ALANINE COMPOUND, AN ADENINE COMPOUND, AN ADENOSINE COMPOUND, AND A QUATERNARY AMMONIUM SALT COMPOUND, AND WHICH INCREASES MISCIBILITY IN A RESIST FILM KABUSHIKI KAISHA TOSHIBA (JP) 2004-03-09 US disclosed
US-20020082264-A1 Medicaments for viral diseases BAYER AKTIENGESELLSCHAFT (DE) 2002-06-27 US disclosed
WO-2002020509-A2 MEDICAMENTS AGAINST VIRAL INFECTIONS BAYER AKTIENGESELLSCHAFT (DE) 2002-03-14 WO disclosed
US-20010049374-A1 Urokinase inhibitors STEELE ANDREW W (US) 2001-12-06 US disclosed
US-6284796-B1 NAPHTHAMIDINE COMPOUNDS ABBOTT LABORATORIES 2001-09-04 US disclosed
US-6258822-B1 ENZYME INHIBITORS OF NAPHTHALENE AMIDINE COMPOUNDS ABBOTT LABORATORIES 2001-07-10 US disclosed
US-6110910-A ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC AGENTS, ANTIRHEUMATIC AGENTS, ANTICARCINOGENIC AGENTS DUPONT PHARMACEUTICALS (US) 2000-08-29 US disclosed
EP-1000018-A2 UROKINASE INHIBITORS Abbott Laboratories (US) 2000-05-17 EP disclosed
CN-1214048-A Benzopyran derivatives having leukotriene-antagonistic action LABROATORIOS MENARINI S A (ES) 1999-04-14 CN disclosed
US-5874441-A TREATMENT OF AUTOIMMUNE DISEASES, INFLAMMATION DUPONT PHARMACEUTICALS COMPANY (US) 1999-02-23 US disclosed
WO-1999005096-A2 UROKINASE INHIBITORS ABBOTT LABORATORIES (US) 1999-02-04 WO disclosed
US-5744281-A P-HYDROXYSTYRENE POLYMER KABUSHIKI KAISHA TOSHIBA (JP) 1998-04-28 US disclosed
EP-0624163-B1 CYCLIC CALCITONIN DERIVATIVES AND METHOD FOR THEIR PRODUCTION SMITHKLINE BEECHAM FARMA (IT) 1998-03-25 EP disclosed
US-5658706-A CONTAINING COMPOUND WHICH DECOMPOSES INTO AN ACID KABUSHIKI KAISHA TOSHIBA (JP) 1997-08-19 US disclosed
US-5639759-A ORGAN TRANSPLANTATION; AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS; SKIN DISORDERS; ANTIARTHRITIC AGENTS; ANTICANCER AGENTS THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) 1997-06-17 US disclosed
EP-0716652-A1 CARBOCYCLIC AND HETEROCYCLIC FUSED-RING QUINOLINECARBOXYLIC ACIDS USEFUL AS IMMUNOSUPPRESSIVE AGENTS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1996-06-19 EP disclosed
US-5428040-A Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1995-06-27 US disclosed
WO-1995006640-A1 CARBOCYCLIC AND HETEROCYCLIC FUSED-RING QUINOLINECARBOXYLIC ACIDS USEFUL AS IMMUNOSUPPRESSIVE AGENTS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1995-03-09 WO disclosed
WO-1995004046-A1 COMPOUNDS AS PDE IV AND TNF INHIBITORS RHONE-POULENC RORER LIMITED (GB) 1995-02-09 WO disclosed
EP-0624163-A1 CYCLIC CALCITONIN DERIVATIVES AND METHOD FOR THEIR PRODUCTION Smithkline Beecham Farmaceutici S.p.A. (IT) 1994-11-17 EP disclosed
WO-1993015106-A1 CYCLIC CALCITONINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION SMITHKLINE BEECHAM FARMACEUTICI S.P.A. (IT) 1993-08-05 WO disclosed
EP-0181121-B1 NOVEL POLYPEPTIDE AND PROCESS FOR PRODUCING THE SAME MITSUBISHI PETROCHEMICAL CO., LTD. (JP) 1992-12-30 EP disclosed
EP-0137534-B1 ONE-POT PROCESS FOR PREPARATION OF 7BETA-AMINO- AND 7BETA-ACYLAMINO- 3-SUBSTITUTED METHYL-3-CEPHEM-4-CARBOXYLIC ACID DERIVATIVES AND PROCESS FOR DEOXYGENATION OF 7BETA-ACYLAMINO-3-CEPHEM-4-CARBOXYLIC ACID 1-OXIDE DERIVATIVES GIST-BROCADES N.V. (NL) 1990-05-16 EP disclosed
US-RE33188-E Peptides for assaying human parathyroid hormone TOYO JOZO KABUSHIKI KAISHA (JP) 1990-03-27 US disclosed
EP-0119705-B1 OCTAPEPTIDE VASOPRESSIN ANTAGONISTS SMITHKLINE BECKMAN CORPORATION (US) 1989-09-06 EP disclosed
US-4719199-A VASORPRESSIN ANTAGONIST SMITHKLINE BECKMAN CORPORATION (US) 1988-01-12 US disclosed
US-4703106-A REDUCING CALCIUM CONCENTRATION OF BLOOD MITSUBISHI PETROCHEMICAL CO., LTD. (JP) 1987-10-27 US disclosed
US-4695627-A PHOSPHORUS PENTACHLORIDE, OLEFIN GIST-BROCADES N.V. (NL) 1987-09-22 US disclosed
US-4684716-A VASOPRESSIN ANTAGONISTS SMITHKLINE BECKMAN CORPORATION (US) 1987-08-04 US disclosed
US-4656250-A NORLEUCINE, TYROSINE, PHENYLALANINE TREATING HYPOPARATHYROIDISM TOYO JOZO KABUSHIKI KAISHA (JP) 1987-04-07 US disclosed
US-4597901-A POLYPEPTIDES, DIURESIS SMITHKLINE BECKMAN CORPORATION (US) 1986-07-01 US disclosed
EP-0181121-A2 Novel polypeptide and process for producing the same MITSUBISHI PETROCHEMICAL CO., LTD. (JP) 1986-05-14 EP disclosed
US-4587045-A Intermediates for preparing octapeptide vasopressin antagonists SMITHKLINE BECKMAN CORPORATION (US) 1986-05-06 US disclosed
US-4542124-A Octapeptide vasopressin antagonists SMITHKLINE BECKMAN CORPORATION (US) 1985-09-17 US disclosed
EP-0137534-A2 One-pot process for preparation of 7beta-amino- and 7beta-acylamino- 3-substituted methyl-3-cephem-4-carboxylic acid derivatives and process for deoxygenation of 7beta-acylamino-3-cephem-4-carboxylic acid 1-oxide derivatives GIST-BROCADES N.V. (NL) 1985-04-17 EP disclosed
EP-0119705-A2 Octapeptide vasopressin antagonists SMITHKLINE BECKMAN CORPORATION (US) 1984-09-26 EP disclosed
US-4409141-A Peptides for assaying human parathyroid hormone TOYO JOZO KABUSHIKI KAISHA (JP) 1983-10-11 US disclosed
US-4400316-A POLYPEPTIDES TOYO JOZO KABUSHIKI KAISHA (JP) 1983-08-23 US disclosed
US-4258193-A FOR IMMOBILIZATION; IMMUNOASSAY, CROSSLINKING OF PROTEINS TOYO JOZO KABUSHIKI KAISHA (JP) 1981-03-24 US disclosed
US-4234578-A ANTIBIOTICS CIBA-GEIGY CORPORATION (US) 1980-11-18 US disclosed
US-4133814-A ANTITUMOR AGENTS ELI LILLY AND COMPANY (US) 1979-01-09 US disclosed
US-4086221-A SERUM CALCIUM REDUCING ACTIVITY TOYO JOZO KABUSHIKI KAISHA (JA) 1978-04-25 US disclosed
US-4075227-A NONSTEROIDAL ELI LILLY AND COMPANY (US) 1978-02-21 US disclosed
US-4075223-A NONSTEROIDAL ELI LILLY AND COMPANY (US) 1978-02-21 US disclosed
US-4024249-A FOR COMBATTING MICROORGANISMS CIBA-GEIGY CORPORATION (US) 1977-05-17 US disclosed
US-4017546-A AROYL PHENYL INDENES AND AROYL PHENYL NAPHTHALENES ELI LILLY AND COMPANY (US) 1977-04-12 US disclosed
US-3962224-A CHEMICAL INTERMEDIATES FOR ANTIBIOTICS MERCK & CO., INC. (US) 1976-06-08 US disclosed
US-3962224-A CHEMICAL INTERMEDIATES FOR ANTIBIOTICS MERCK & CO., INC. (US) 1976-06-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (48 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110144080-A1 PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS GRK3, GRK2, NR0B2 GSK3B 449/4885HDAC1 677/4885HDAC8 860/4885
US-20060035922-A1 Triazolopyridinylsulfanyl derivatives as p38 MAP kinase inhibitors MAPK1, MAPKAPK5, MAPKAPK3 GSK3B 707/4885HDAC1 714/4885HDAC8 806/4885
US-20120289501-A1 Benzene-fused 6-membered oxygen-containing heterocyclic derivatives of bicyclic heteroaryls CYP1B1, CYP11B2, CCNI GSK3B 1516/4885HDAC1 579/4885HDAC8 1356/4885
US-20200055825-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR AR, MDM2, ESRRA GSK3B 1229/4885HDAC1 500/4885HDAC8 629/4885
US-20020082264-A1 Medicaments for viral diseases IRF3, STING1, EIF2AK2 GSK3B 672/4885HDAC1 1380/4885HDAC8 726/4885
US-20070149577-A1 Compounds with medicinal effects due to interaction with the glucocorticoid receptor NR3C1, NR3C2, MC2R GSK3B 1404/4885HDAC1 411/4885HDAC8 683/4885
US-20190135828-A1 HEPATITIS C VIRUS INHIBITOR AND USES THEREOF HAVCR2, ZC3HAV1, HCCS GSK3B 2012/4885HDAC1 1311/4885HDAC8 1620/4885
US-20170042917-A1 SUBSTITUTED BICYCLIC COMPOUNDS S1PR1, S1PR3, S1PR2 GSK3B 1819/4885HDAC1 811/4885HDAC8 2146/4885
US-20240076295-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ADRM1, BRAP, VHL GSK3B 2139/4885HDAC1 908/4885HDAC8 827/4885
US-20160052888-A1 SUBSTITUTED BICYCLIC COMPOUNDS S1PR1, S1PR3, S1PR2 GSK3B 1819/4885HDAC1 811/4885HDAC8 2146/4885
US-20100267631-A1 APOLIPOPROTEIN A-I MIMICS APOB, APOL1, LIPG GSK3B 3441/4885HDAC1 3318/4885HDAC8 3979/4885
US-20210101891-A1 HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF EP300, HDAC11, HDAC1 GSK3B 612/4885HDAC1 3/4885HDAC8 7/4885
US-10166249-B2 Substituted bicyclic compounds S1PR1, S1PR3, S1PR2 GSK3B 1819/4885HDAC1 811/4885HDAC8 2146/4885
US-12539292-B2 BRM targeting compounds and associated methods of use ADRM1, SUMO2, BAZ1A GSK3B 1760/4885HDAC1 422/4885HDAC8 418/4885
US-20170327469-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR AR, MDM2, ESRRA GSK3B 1229/4885HDAC1 500/4885HDAC8 629/4885
US-20100280267-A1 METHOD FOR PRODUCING CYCLOPROPANE CARBOXYLIC ACID COMPOUND AND INTERMEDIATE THEREFOR FAR1, CYP51A1, CYP4A11 GSK3B 3793/4885HDAC1 901/4885HDAC8 793/4885
US-20070117823-A1 N-sulfamoyl-N'-benzopyranpiperidine compounds and uses thereof SCN2A, NAPEPLD, SCN5A GSK3B 2422/4885HDAC1 626/4885HDAC8 2030/4885
US-20090192148-A1 Organic Compounds REN, ACE, AGTR1 GSK3B 4475/4885HDAC1 994/4885HDAC8 3023/4885
US-20200281952-A1 SUBSTITUTED BICYCLIC COMPOUNDS S1PR1, S1PR3, S1PR2 GSK3B 1819/4885HDAC1 811/4885HDAC8 2146/4885
US-12312316-B2 Compounds and methods for the targeted degradation of androgen receptor AR, MDM2, ESRRA GSK3B 1229/4885HDAC1 500/4885HDAC8 629/4885
US-20200038378-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ADRM1, BRAP, VHL GSK3B 2139/4885HDAC1 908/4885HDAC8 827/4885
US-20220331346-A1 SUBSTITUTED BICYCLIC COMPOUNDS S1PR1, S1PR3, S1PR2 GSK3B 1819/4885HDAC1 811/4885HDAC8 2146/4885
US-20160324923-A1 APOLIPOPROTEIN A-I MIMICS APOB, APOL1, LIPG GSK3B 3441/4885HDAC1 3318/4885HDAC8 3979/4885
US-11701373-B2 Substituted bicyclic compounds S1PR1, S1PR3, S1PR2 GSK3B 1819/4885HDAC1 811/4885HDAC8 2146/4885
US-20180030003-A1 TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE NR1H4, SLC10A1, SLC10A2 GSK3B 176/4885HDAC1 807/4885HDAC8 483/4885
US-20120029226-A1 METHOD FOR THE SYNTHESIS OF CHIRAL ALPHA-ARYL PROPIONIC ACID DERIVATIVES GRIA1, GRIA3, GRIA2 GSK3B 509/4885HDAC1 1277/4885HDAC8 3285/4885
US-20110263560-A1 Organic Compounds REN, ACE, OTC GSK3B 4596/4885HDAC1 980/4885HDAC8 2675/4885
US-20120010181-A1 COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS TNF, ADAMTS1, ADAMTS7 GSK3B 403/4885HDAC1 475/4885HDAC8 799/4885
US-11058696-B2 Substituted bicyclic compounds S1PR1, S1PR3, S1PR2 GSK3B 1819/4885HDAC1 811/4885HDAC8 2146/4885
US-10640515-B2 Hepatitis C virus inhibitor and uses thereof CLIC1, HAVCR2, ZC3HAV1 GSK3B 3564/4885HDAC1 665/4885HDAC8 2314/4885
US-20190300521-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ADRM1, BRAP, VHL GSK3B 2139/4885HDAC1 908/4885HDAC8 827/4885
US-20150141330-A1 APOLIPOPROTEIN A-I MIMICS APOB, APOL1, LIPG GSK3B 3441/4885HDAC1 3318/4885HDAC8 3979/4885
US-20160185763-A1 LIQUID CRYSTAL STABILIZER, LIQUID CRYSTAL COMPOSITION INCLUDING THE SAME, AND LIQUID CRYSTAL DISPLAY INCLUDING THE SAME PYM1, YBX3, MLX GSK3B 1542/4885HDAC1 2958/4885HDAC8 4178/4885
US-20220387615-A1 COMPOSITIONS COMPRISING ENZYME CLEAVABLE LINKER PLATFORMS AND CONJUGATES THEREOF ADAM17, ADAM8, ADAM33 GSK3B 3088/4885HDAC1 1404/4885HDAC8 1265/4885
US-20040072871-A1 Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them MMP11, MMP13, CBR1 GSK3B 1911/4885HDAC1 573/4885HDAC8 1342/4885
US-20220002278-A9 HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF EP300, HDAC11, HDAC1 GSK3B 612/4885HDAC1 3/4885HDAC8 7/4885
US-20260041671-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ADRM1, VHL, BAZ1A GSK3B 2237/4885HDAC1 653/4885HDAC8 677/4885
US-20090312304-A1 ORGANIC COMPOUNDS REN, ACE, PIGO GSK3B 4436/4885HDAC1 1032/4885HDAC8 2680/4885
US-10183917-B2 Tricyclic compounds and uses thereof in medicine NR1H4, SLC10A1, SLC10A2 GSK3B 176/4885HDAC1 807/4885HDAC8 483/4885
US-20170304332-A1 SUBSTITUTED BICYCLIC COMPOUNDS S1PR1, S1PR3, S1PR2 GSK3B 1819/4885HDAC1 811/4885HDAC8 2146/4885
US-20130231459-A1 APOLIPOPROTEIN A-I MIMICS APOB, APOL1, LIPG GSK3B 3441/4885HDAC1 3318/4885HDAC8 3979/4885
US-10709719-B2 Substituted bicyclic compounds S1PR1, S1PR3, S1PR2 GSK3B 1819/4885HDAC1 811/4885HDAC8 2146/4885
US-11427548-B2 Compounds and methods for the targeted degradation of androgen receptor AR, MDM2, ESRRA GSK3B 1229/4885HDAC1 500/4885HDAC8 629/4885
US-12172989-B2 Histone acetyltransferase (HAT) inhibitor and use thereof EP300, HDAC11, HDAC1 GSK3B 612/4885HDAC1 3/4885HDAC8 7/4885
US-20050256124-A1 Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto MCHR1, MCHR2, MC1R GSK3B 2163/4885HDAC1 1915/4885HDAC8 2601/4885
US-20010049374-A1 Urokinase inhibitors SERPINE1, PLAU, SERPINB1 GSK3B 4628/4885HDAC1 1182/4885HDAC8 3118/4885
US-20190076450-A1 SUBSTITUTED BICYCLIC COMPOUNDS S1PR1, S1PR3, S1PR2 GSK3B 1819/4885HDAC1 811/4885HDAC8 2146/4885
US-20090239899-A1 Triazolopyridinylsulfanyl Derivatives As P38 Map Kinase Inhibitors MAPK1, MAPKAPK5, MAPKAPK3 GSK3B 603/4885HDAC1 638/4885HDAC8 721/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.