Hydrochloric Acid

Hydrochloric Acid

SCHEMBL12040

Cl.O=C1C=Cc2cc3cc4ccccc4cc3cc2C1=O

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCHE known ✓ P06276 1/20 0.52
ACHE known ✓ P22303 1/20 0.52
MAOA known ✓ P21397 1/20 0.37
MAOB known ✓ P27338 1/20 0.37
GSTP1 known ✓ P09211 1/20 0.33
GAA known ✓ P10253 1/20 0.32
PTGS2 known ✓ P35354 1/20 0.32
GRIN2D known ✓ O15399 1/20 0.31
GRIN3B known ✓ O60391 1/20 0.31
GRIN1 known ✓ Q05586 1/20 0.31
GRIN2A known ✓ Q12879 1/20 0.31
GRIN2B known ✓ Q13224 1/20 0.31
GRIN2C known ✓ Q14957 1/20 0.31
GRIN3A known ✓ Q8TCU5 1/20 0.31
PTPRC P08575 5/20 0.52
ALDH1A1 P00352 5/20 0.52
HSD17B10 Q99714 4/20 0.52
HPGD P15428 4/20 0.52
CES1 P23141 3/20 0.52
ALOX15 P16050 3/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL10785895 1.00 PTPRC (0.52) PTPRCALDH1A1HSD17B10HPGDCES1
SCHEMBL27552426 0.98 PTPRC (0.53) PTPRCALDH1A1HSD17B10HPGDCES1
SCHEMBL448680 0.98 PTPRC (0.53) PTPRCALDH1A1HSD17B10HPGDCES1
SCHEMBL146910 0.98 PTPRC (0.53) PTPRCALDH1A1HSD17B10HPGDCES1
SCHEMBL29391697 0.98 PTPRC (0.53) PTPRCALDH1A1HSD17B10HPGDCES1
Hydrochloric Acid SCHEMBL27713616 0.96 PTPRC (0.55) PTPRCALDH1A1HSD17B10HPGDCES1
Hydrochloric Acid SCHEMBL29415866 0.96 PTPRC (0.55) PTPRCALDH1A1HSD17B10HPGDCES1
Anthracene SCHEMBL27939488 0.96 PTPRC (0.55) PTPRCALDH1A1HSD17B10HPGDCES1
Hydrochloric Acid SCHEMBL30337382 0.94 PTPRC (0.53) PTPRCALDH1A1HSD17B10HPGDCES1
SCHEMBL1118356 0.94 PTPRC (0.57) PTPRCALDH1A1HSD17B10HPGDCES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 385 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12637492-B2 Peptide inhibitors of focal adhesion kinase activity and uses thereof ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2026-05-26 US disclosed
US-12521386-B2 Small molecule inhibitors of the androgen receptor activity and/or expression and uses thereof ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2026-01-13 US disclosed
US-12509468-B2 Quindoline compounds and uses thereof ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2025-12-30 US disclosed
US-20250276953-A1 SMALL MOLECULE SIRTUIN INHIBITORS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2025-09-04 US disclosed
US-20250189527-A1 COMPOSITIONS AND METHODS FOR DETECTING, PREDICTING RISK OF DEVELOPING, AND TREATING LEPTOMENINGEAL DISEASE DUKE UNIVERSITY 2025-06-12 US disclosed
CN-119487019-A Piperazine derivatives for HIV therapy VIIV保健公司 2025-02-18 CN disclosed
US-20240239764-A1 SUBSTITUTED AMINOBENZYL HETEROARYL COMPOUNDS AS EGFR AND/OR PI3K INHIBITORS THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2024-07-18 US disclosed
US-20240150452-A1 MULTIFUNCTIONAL PROTEIN MOLECULES COMPRISING DECORIN AND USE THEREOF CATALENT PHARMA SOLUTIONS, LLC 2024-05-09 US disclosed
US-20240124419-A1 SMALL MOLECULE INHIBITORS OF GRP78 AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2024-04-18 US disclosed
US-11944626-B2 Small molecule inhibitors of ALDH and uses thereof THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2024-04-02 US disclosed
US-20060084647-A1 Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2006-04-20 US disclosed
US-20060078903-A1 Methods and compositions for the diagnosis and treatment of cyclin A-1 associated conditions THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) 2006-04-13 US disclosed
US-20050288239-A1 Anticancer glycoside compounds NORTHWESTERN UNIVERSITY (US) 2005-12-29 US disclosed
US-20050261232-A1 Non-natural ribonuclease conjugates as cytotoxic agents QUINTESSENCE BIOSCIENCES, INC. (US) 2005-11-24 US disclosed
US-20050232927-A1 Compositions and methods for characterizing, regulating, diagnosing, and treating cancer THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2005-10-20 US disclosed
US-20050234135-A1 Gossypol co-crystals and the use thereof THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2005-10-20 US disclosed
WO-2005085227-A1 INHIBITORS OF AKT ACTIVITY SMITHKLINE BEECHAM CORPORATION (US) 2005-09-15 WO disclosed
EP-1423105-A2 COMBINATIONS OF DMXAA AND OTHER ANTI-CANCER AGENTS Cancer Research Technology Limited (GB) 2004-06-02 EP disclosed
WO-2003099296-A1 METHOD OF TREATING MULTIPLE SCLEROSIS PHARMACIA & UPJOHN COMPANY (US) 2003-12-04 WO disclosed
WO-2003020259-A2 COMBINATIONS OF DMXAA AND OTHER ANTI-CANCER AGENTS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2003-03-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240150452-A1 MULTIFUNCTIONAL PROTEIN MOLECULES COMPRISING DECORIN AND USE THEREOF CD2BP2, DSTN, SDCBP BCHE 3225/4885ACHE 3889/4885MAOA 3138/4885
US-20240124419-A1 SMALL MOLECULE INHIBITORS OF GRP78 AND USES THEREOF HSPA5, HSPA2, PSMG3 BCHE 4732/4885ACHE 3780/4885MAOA 4847/4885
US-20240239764-A1 SUBSTITUTED AMINOBENZYL HETEROARYL COMPOUNDS AS EGFR AND/OR PI3K INHIBITORS EGFR, ERBB2, ERBB3 BCHE 4767/4885ACHE 4848/4885MAOA 3112/4885
US-20050234135-A1 Gossypol co-crystals and the use thereof BAX, BCL2, CASP8 BCHE 2973/4885ACHE 4862/4885MAOA 4799/4885
US-12509468-B2 Quindoline compounds and uses thereof TPD52L2, BRDT, RECQL BCHE 3444/4885ACHE 1819/4885MAOA 4390/4885
US-20060084647-A1 Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof BCL2, BAD, BCL2L1 BCHE 4308/4885ACHE 4860/4885MAOA 4238/4885
US-11944626-B2 Small molecule inhibitors of ALDH and uses thereof ALDH2, ALDH1A1, ALDH3A1 BCHE 3230/4885ACHE 2856/4885MAOA 1254/4885
US-20250276953-A1 SMALL MOLECULE SIRTUIN INHIBITORS AND USES THEREOF SIRT6, SIRT2, SIRT1 BCHE 3927/4885ACHE 1554/4885MAOA 3442/4885
US-12637492-B2 Peptide inhibitors of focal adhesion kinase activity and uses thereof PTK2, ILK, FPR2 BCHE 4380/4885ACHE 4690/4885MAOA 4830/4885
US-20050261232-A1 Non-natural ribonuclease conjugates as cytotoxic agents RNASE1, RNASEL, RNASEH1 BCHE 1499/4885ACHE 3796/4885MAOA 3586/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.